2-methylpropyl (2S)-2-aminopropanoate → N-[(6methoxybenzothiophen-2-yl)acetyl]alanine iso-butyl ester

HRID 1859140Notes

Reaction equation

HRID 1859140 reaction equation
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]2[CH:7]=[C:8]([CH2:10][C:11]([OH:13])=O)[S:9][C:5]=2[CH:4]=1.[CH2:16]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH2:23])[CH:17]([CH3:19])[CH3:18]>>[CH2:16]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH:23][C:11](=[O:13])[CH2:10][C:8]1[S:9][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[CH:15]=[CH:14][C:6]=2[CH:7]=1)[CH:17]([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 137435562-methylpropyl (2S)-2-aminopropanoateHCID 22491908(6-Methoxybenzothiophen-2-yl)acetic acid

Product 1

HCID 22894977N-[(6methoxybenzothiophen-2-yl)acetyl]alanine iso-butyl ester

Procedure

Following General Procedure I' above, and using (6-methoxybenzothiophen-2-yl)acetic acid and alanine iso-butyl ester (prepared following General Procedure J' above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-2195035c69944e468071d975925649cf
Source dataset
uspto-grants-2000_11
Patent number
US06153652

Reaction notes

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