3-Thiophenacetic acid → N-[(3thienyl)acetyl]alanine Iso-butyl Ester

HRID 1859145Notes

Reaction equation

HRID 1859145 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([OH:9])=O)=[CH:2]1.[CH2:10]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH2:17])[CH:11]([CH3:13])[CH3:12]>>[CH2:10]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH:17][C:7](=[O:9])[CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[CH:11]([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 234043-Thiophenacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 53969374N-[(3thienyl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I' above, and using 3-thiopheneacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure J' above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-f78dc2fcdb6547708da9176a56c9edde
Source dataset
uspto-grants-2000_11
Patent number
US06153652

Reaction notes

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