HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexaneacetic acid → N-(cyclohexyIacetyl)-L-alanine iso-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexaneacetic acid | HCID 21363 | — |
| Reactant | 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride | HCID 86584981 | — |
| Product | N-(cyclohexyIacetyl)-L-alanine iso-butyl ester | HCID 54223838 | — |
Reaction Steps
Following General Procedure B' above, and using cyclohexylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example B' above), the title compound was prepared as a solid having a melting point of 92° C.-93° C. The reaction was monitored by tlc on silica gel (Rf=0.39 in 1:3 EtOAc:hexane) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153652 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-ba5c96120fa8427b89f637b44d09400f |
| Source note | uspto-grants-2000_11 |