Methanol → Methyl [2-(aminomethyl)phenyl]acetate--hydrogen chloride (1/1)

HRID 1859163Notes

Reaction equation

Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([OH:13])=[O:12].S(Cl)([Cl:16])=O.[CH3:18]O>>[ClH:16].[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([O:13][CH3:18])=[O:12]

Participants

Reactant 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 5743497(2-(Aminomethyl)phenyl)acetic acid hydrochloride

Product 1

HCID 21185367Methyl [2-(aminomethyl)phenyl]acetate--hydrogen chloride (1/1)

Procedure

2-(Aminomethyl)-benzeneacetate hydrochloride was stirred in dry methanol. Thionyl chloride (1.1 eq.) was added dropwise and the mixture was stirred at room temperature overnight to provide for (methyl 2-(aminomethyl)-benzeneacetate hydrochloride as a white solid.

Sources & evidence

ORD record: ord-7c6b8b5252994161a81cc7cfc6a05970
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06153652

Reaction notes

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