Hydrochloric Acid → Ethyl acetate methanol ammonium hydroxide

Participants

Reaction Steps

The product from step b) (66.0 mg, 0.12 mmol), tetrhydrofuran (5 mL) and 5 mL of 5 M HCl (aq) were heated at 50° C. for 45 min. The mixture was poured into ethyl acetate and dilute ammonium hydroxide. The organic phase was washed 3 times with dilute ammonium hydroxide and once with water, and then evaporated. Chromatography (ethyl acetate/methanol/ammonium hydroxide: 95/5/1) gave 54 mg of the title product.

Provenance & Evidence