Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Hydroxybenzonitrile | HCID 11907 | — |
| Reactant | Methyl (2E)-2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyprop-2-enoate | HCID 11782200 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Azoxystrobin | HCID 3034285 | — |
Reaction Steps
A mixture of 2-cyanophenol (12.6 g), potassium carbonate (8.28 g) and (E)-methyl 2-[2-(6-chloropyrimidin4-yloxy)phenyl]-3-methoxypropenoate (33.0 g) was heated at 120° C. for 3 hours. The mixture was then cooled to 100° C. after which methanol (40 ml) was added to help cooling to 65° C. The resulting mixture was cooled to 0-5° C. and kept at this temperature for 1 hour. The mixture was filtered to leave (E)-methyl 2-[2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate as the residue (87.5%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06153750 |
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| Source dataset | uspto-grants-2000_11 |
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| ORD ID | ord-dc263c41d6084113936df31f0ac54159 |
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| Source note | uspto-grants-2000_11 |
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