Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Hydroxybenzonitrile | HCID 11907 | — |
| Reactant | Methyl (2E)-2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyprop-2-enoate | HCID 11782200 | — |
| Solvent | Water | HCID 962 | — |
| Product | Azoxystrobin | HCID 3034285 | — |
Reaction Steps
A mixture of 2-cyanophenol (13.2 g), potassium carbonate (20.7 g), polyethylene glycol 400 (20.0 g), (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3 -methoxypropenoate (32.8 g) and water (77 g) was heated at 96° C. for 16 hours. The temperature of the solution was then raised to 105° C. and held for a further 12 hours. Any distillates were allowed to come off under atmospheric conditions. (E)-methyl 2-[2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate was produced (86.6 area %).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06153750 |
|---|
| Source dataset | uspto-grants-2000_11 |
|---|
| ORD ID | ord-cd11ed5b2e644a10911914bd3057a871 |
|---|
| Source note | uspto-grants-2000_11 |
|---|
