HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamide → N-acetyliminodiacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamide | HCID 178 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Iminodiacetic acid | HCID 8897 | — |
| Reactant | Acetylglycine | HCID 10972 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | N-acetyliminodiacetic acid | HCID 10130190 | 89% |
Reaction Steps
A 300 mL autoclave was charged with acetamide (VII) (11.8 g, 0.2 mole), 95% paraformaldehyde (13.6 g, 0.43 mole), water (12.9 g, 0.72 mole), DME (90 mL), and CO2 (CO)8 (4.1 g, 0.012 mole) and pressurized to 1500 psi (10,345 kPa) CO:H2 (95:5) at 25° C. for 30 min. HPLC analysis of this stream gave an 89% yield of (XVI), 1% (XIV), and 8% (XVIII).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153753 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-86001e533cd5446da4aea7bf2361e812 |
| Source note | uspto-grants-2000_11 |