(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4]oxazepine → (r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4] oxazepine hydrochloride

HRID 1859423Notes

Reaction equation

HRID 1859423 reaction equation
[ClH:1].O1CCOCC1.[CH3:8][O:9][C:10]1[CH:39]=[CH:38][C:13]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)=[CH:12][CH:11]=1>ClCCl>[ClH:1].[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 15520941(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4]oxazepineHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 22975054(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4] oxazepine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.0 ml of 4 M hydrochloric acid/dioxane was added to a solution of (R)-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl] dibenzo[b,e][1,4]oxazepine (0.63 g) in dichloromethane (10 ml), and they were stirred for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was recrystallized from a mixed solvent of acetone and ether to obtain the title compound in the form of a white solid (496 mg, 73%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe obtained residue was recrystallized from a mixed solvent of acetone and ether

Sources & evidence

ORD record
ord-a1c5a4c9a3bd412c829a6b137d83a879
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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