(r)-5,11-Dihydro-5-[1-[3-(4-methoxyphenyl)propyl]piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine → (r)-5,11-Dihydro-5-[1-[3-(4-methoxyphenyl)propyl]piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine hydrochloride

HRID 1859431Notes

Reaction equation

HRID 1859431 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][C@@H:20]2[CH2:25][N:26]2[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[CH2:30][O:29][C:28]3[CH:37]=[CH:38][CH:39]=[CH:40][C:27]2=3)=[CH:12][CH:11]=1>ClCCl>[ClH:1].[CH3:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][C@@H:20]2[CH2:25][N:26]2[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=3[CH2:30][O:29][C:28]3[CH:37]=[CH:38][CH:39]=[CH:40][C:27]2=3)=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 12018618(r)-5,11-Dihydro-5-[1-[3-(4-methoxyphenyl)propyl]piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepineHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 69900804(r)-5,11-Dihydro-5-[1-[3-(4-methoxyphenyl)propyl]piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.0 ml of 4 M hydrochloric acid/ethyl acetate was added to a solution of (R)-5,11-dihydro-5-[1-[3-(4-methoxyphenyl)propyl]piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (196 mg) in dichloromethane (5 ml), and they were stirred for 2 hours. The solvent was evaporated under reduced pressure. The title compound was obtained in the form of a light yellow solid (180 mg, 85%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9e946c50541f457e98952d84e89bbe98
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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