Hydrogen chloride-ethyl acetate → (r)-5,11-Dihydro-5-[1-(3,4-methylenedioxyphenethyl)piperidine-2-yl-methyl]dibenzo[b,e][1,4]oxazepine hydrochloride

HRID 1859435Notes

Reaction equation

HRID 1859435 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]1[O:40][C:39]2[CH:38]=[CH:37][C:12]([CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][CH2:18][CH2:17][C@@H:16]3[CH2:21][N:22]3[C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=4[CH2:26][O:25][C:24]4[CH:33]=[CH:34][CH:35]=[CH:36][C:23]3=4)=[CH:11][C:10]=2[O:9]1>ClCCl>[ClH:1].[CH2:8]1[O:40][C:39]2[CH:38]=[CH:37][C:12]([CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][CH2:18][CH2:17][C@@H:16]3[CH2:21][N:22]3[C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=4[CH2:26][O:25][C:24]4[CH:33]=[CH:34][CH:35]=[CH:36][C:23]3=4)=[CH:11][C:10]=2[O:9]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69897309(R)-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl)piperidine-2-ylmethyl] dibenzo [b,e][1,4] oxazepine

Product 1

HCID 69902670(r)-5,11-Dihydro-5-[1-(3,4-methylenedioxyphenethyl)piperidine-2-yl-methyl]dibenzo[b,e][1,4]oxazepine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 ml of 4 M hydrochloric acid/ethyl acetate was added to a solution of (R)-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl) piperidine-2-ylmethyl] dibenzo [b,e][1,4] oxazepine (171 mg) in dichloromethane (5 ml), and they were stirred for 2 hours. The solvent was evaporated under reduced pressure. The title compound was obtained in the form of a white solid (150 mg, 80%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-abea474c3af9409fa13019acb005433f
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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