(R)-5-[1-(4-chlorophenethyl)piperidine-2-ylmethyl]-5,11-dihydro-dibenzo[b,e][1,4]oxazepine → (R)-5-[1-(4-chlorophenethyl)piperidine-2-ylmethyl]-5,11-dihydrodibenzo [b,e][1,4]oxazepine Hydrochloride

HRID 1859439Notes

Reaction equation

HRID 1859439 reaction equation
Cl.C(OCC)(=O)C.[Cl:8][C:9]1[CH:38]=[CH:37][C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][C@@H:16]2[CH2:21][N:22]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[CH2:26][O:25][C:24]3[CH:33]=[CH:34][CH:35]=[CH:36][C:23]2=3)=[CH:11][CH:10]=1>ClCCl>[ClH:8].[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][C@@H:16]2[CH2:21][N:22]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[CH2:26][O:25][C:24]3[CH:33]=[CH:34][CH:35]=[CH:36][C:23]2=3)=[CH:37][CH:38]=1

Participants

4

Reactant 2

HCID 12018619(R)-5-[1-(4-chlorophenethyl)piperidine-2-ylmethyl]-5,11-dihydro-dibenzo[b,e][1,4]oxazepineHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 69900813(R)-5-[1-(4-chlorophenethyl)piperidine-2-ylmethyl]-5,11-dihydrodibenzo [b,e][1,4]oxazepine Hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 ml of 4 M hydrochloric acid/ethyl acetate was added to a solution of (R)-5-[1-(4-chlorophenethyl)piperidine-2-ylmethyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine (160 mg) in dichloromethane (5 ml), and they were stirred for 2 hours. The solvent was evaporated under reduced pressure. The title compound was obtained in the form of a white solid (155 mg, 87%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b0d1b6d5144c4e90bd2a9559034279b7
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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