(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine → (r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine hydrochloride

HRID 1859448Notes

Reaction equation

HRID 1859448 reaction equation
[ClH:1].O1CCOCC1.[CH3:8][O:9][C:10]1[CH:37]=[CH:36][C:13]([CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][C@@H:18]([N:21]3[C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=4[CH2:25][O:24][C:23]4[CH:32]=[CH:33][CH:34]=[CH:35][C:22]3=4)[CH2:17]2)=[CH:12][CH:11]=1>ClCCl>[ClH:1].[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][C@@H:18]([N:21]3[C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=4[CH2:25][O:24][C:23]4[CH:32]=[CH:33][CH:34]=[CH:35][C:22]3=4)[CH2:17]2)=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 9867704(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepineHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 9867703(r)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.0 ml of 4 M hydrochloric acid/dioxane was added to a solution of (R)-5,11-dihydro-5-[1-(4-methoxyphenethyl)pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine (360 mg, 0.9 mmol) in dichloromethane (10 ml), and they were stirred for 1 hour. The solvent was evaporated under reduced pressure. The obtained residue was crystallized from ethanol to obtain the title compound in the form of a white solid (302 mg, 77%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe obtained residue was crystallized from ethanol

Sources & evidence

ORD record
ord-aa8b9e4929524ee190d19d5d70a957c8
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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