Ether hydrochloride → (r)-5,11-Dihydro-5-[1-[3-(4-methoxyphenyl)propyl]pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine hydrochloride

HRID 1859459Notes

Reaction equation

HRID 1859459 reaction equation
[ClH:1].C(OCC)C.[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][N:18]2[CH2:22][CH2:21][C@@H:20]([N:23]3[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[CH2:27][O:26][C:25]4[CH:34]=[CH:35][CH:36]=[CH:37][C:24]3=4)[CH2:19]2)=[CH:11][CH:10]=1>ClCCl>[ClH:1].[CH3:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][CH2:17][N:18]2[CH2:22][CH2:21][C@@H:20]([N:23]3[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[CH2:27][O:26][C:25]4[CH:34]=[CH:35][CH:36]=[CH:37][C:24]3=4)[CH2:19]2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 12148706(r)-5,11-Dihydro-5-[1-[3-(4-methoxyphenyl)propyl]pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine

Product 1

HCID 69900161(r)-5,11-Dihydro-5-[1-[3-(4-methoxyphenyl)propyl]pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.0 ml of 2 M hydrochloric acid/ethyl ether was added to a solution of (R)-5,11-dihydro-5-[1-[3-(4-methoxyphenyl)propyl]pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine (78 mg, 0.19 mmol) in dichloromethane, and they were stirred for 1 hour. The solvent was evaporated under reduced pressure to obtain the title compound in the form of a light yellow solid (73 mg, 86%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-cd2dec55b2df4eef9ddc6d37f95b6e76
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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