Sodium Hydroxide → HCID 69900710, compound

HRID 1859460Notes

Reaction equation

HRID 1859460 reaction equation
[N+](C1C=CC(C([O:10][C@H:11]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]4[O:24][CH2:25][O:26][C:20]=4[CH:19]=3)[CH2:12]2)=O)=CC=1)([O-])=O.[OH-].[Na+]>CO>[OH:10][C@H:11]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]3[O:24][CH2:25][O:26][C:20]=3[CH:19]=2)[CH2:12]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69899662HCID 69899662, compound

Product 1

HCID 69900710HCID 69900710, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)-3-(4-Nitrobenzoyloxy)-1-(3,4-methylenedioxyphenethyl) pyrrolidine (474 mg, 1.23 mmol) was dissolved in methanol (10 ml). 1 M-NaOH (1.5 ml) was added dropwise in the obtained mixture. After stirring at room temperature for 1 hour, the solvent was evaporated under reduced pressure. The residue was distributed in water and ethyl acetate. The organic layer was dried, and the solvent was evaporated under reduced pressure to obtain (S)-3-hydroxy-1-(3,4-methylenedioxyphenethyl) pyrrolidine in the form of a light yellow solid (281 mg, 97%).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe organic layer was dried
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-2bd73bec78064ec1b07cf916a1dea568
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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