Ether hydrochloride → (R)-5-[1-(4-Chlorophenethyl)pyrrolidine-3-yl]-5,11-dihydrodibenzo [b,e][1,4]oxazepine Hydrochloride

HRID 1859467Notes

Reaction equation

HRID 1859467 reaction equation
Cl.C(OCC)C.[Cl:7][C:8]1[CH:35]=[CH:34][C:11]([CH2:12][CH2:13][N:14]2[CH2:18][CH2:17][C@@H:16]([N:19]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[CH2:23][O:22][C:21]4[CH:30]=[CH:31][CH:32]=[CH:33][C:20]3=4)[CH2:15]2)=[CH:10][CH:9]=1>ClCCl>[ClH:7].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:12][CH2:13][N:14]2[CH2:18][CH2:17][C@@H:16]([N:19]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[CH2:23][O:22][C:21]4[CH:30]=[CH:31][CH:32]=[CH:33][C:20]3=4)[CH2:15]2)=[CH:34][CH:35]=1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 12018624(R)-5-[1-(4-chlorophenethyl) pyrrolidine-3-yl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine

Product 1

HCID 22975055(R)-5-[1-(4-Chlorophenethyl)pyrrolidine-3-yl]-5,11-dihydrodibenzo [b,e][1,4]oxazepine Hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.0 ml of 2 M hydrochloric acid/ethyl ether was added to a solution of (R)-5-[1-(4-chlorophenethyl)pyrrolidine-3-yl]-5,11-dihydro-dibenzo[b,e][1,4]oxazepine (44 mg, 0.11 mmol) in dichloromethane, and they were stirred for 1 hour. The solvent was evaporated under reduced pressure to obtain the title compound in the form of a light yellow solid (42 mg, 87%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-8180f569c99948e4869feee6ae9e6cb9
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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