5,11-dihydro-5-[2-[N-(4-methoxyphenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine → 5,11-Dihydro-5-[2-[N-(4-methoxyphenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine Hydrochloride

HRID 1859470Notes

Reaction equation

HRID 1859470 reaction equation
[ClH:1].O1CCOCC1.[CH3:8][O:9][C:10]1[CH:36]=[CH:35][C:13]([CH2:14][CH2:15][N:16]([CH2:18][CH2:19][N:20]2[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[CH2:24][O:23][C:22]3[CH:31]=[CH:32][CH:33]=[CH:34][C:21]2=3)[CH3:17])=[CH:12][CH:11]=1>ClCCl>[ClH:1].[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:14][CH2:15][N:16]([CH2:18][CH2:19][N:20]2[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[CH2:24][O:23][C:22]3[CH:31]=[CH:32][CH:33]=[CH:34][C:21]2=3)[CH3:17])=[CH:35][CH:36]=1

Participants

4

Reactant 2

HCID 186255925,11-dihydro-5-[2-[N-(4-methoxyphenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepineHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 186256105,11-Dihydro-5-[2-[N-(4-methoxyphenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine Hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3 ml of 4 M hydrochloric acid/dioxane was added to a solution of 5,11-dihydro-5-[2-[N-(4-methoxyphenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine (423 mg, 1.09 mmol) in dichloromethane (10 ml), and they were stirred for 1 hour. The solvent was evaporated under reduced pressure. The residue was recrystallized from a solvent mixture of ethyl acetate and hexane to obtain the title compound in the form of a white solid (389 mg, 84%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from a solvent mixture of ethyl acetate and hexane

Sources & evidence

ORD record
ord-b20e5fed4bf24aedad4110aa70a117c8
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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