Methyl morpholine oxide → HCID 56994186, compound

Participants

Reaction Steps

—Tetrapropylammonium perruthenate (0.180 g) was added to a solution of (3β,5α,20S)-4,4,20-trimethylpregna-8,14-diene-3,21-diol 3-benzoate (WO09852965; 4.62 g) and 4-methylmorpholine N-oxide (3.50 g) in acetone (80 ml). After 30 min. stirring at room temperature the reaction mixture was filtered over dicalite and silica. The filtrate was concentrated under reduced pressure, to give (3β,5α,20S)-3-(benzoyloxy)-4,4-dimethylpregna-8,14-diene-20-carboxaldehyde (4.28 g) which was used in the following step without further purification.

Provenance & Evidence