2-Methylimidazole → HCID 9908568, compound

HRID 1859486Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([CH3:12])[N:3]=1.[CH3:13][C:14]1[NH:15][CH:16]=[CH:17][N:18]=1.[CH2:19]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>O1CCOCC1>[CH2:19]([N:26]1[CH2:31][CH2:30][N:29]([C:2]2[N:7]=[C:6]([N:15]3[CH:16]=[CH:17][N:18]=[C:14]3[CH3:13])[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([CH3:12])[N:3]=2)[CH2:28][CH2:27]1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of 2,4-dichloro-6-methyl-5-nitropyrimidine (175 mg, 0.84 mmol) in dioxane (5 mL) at 80° C. was added 2-methylimidazole (85 mg, 0.84 mmol) and 1-benzylpiperazine (148 μL, 0.84 mmol). The solution was stirred overnight at 80° C., cooled, and directly chromatographed (1/1 hexane diethyl ether) to yield the title compound (u).

Workup

temperaturecooled
customdirectly chromatographed (1/1 hexane diethyl ether)

Sources & evidence

ORD record: ord-dd6df44c4b024f35bd3e3a391e38d15b
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528513B2

Reaction notes

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