HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 4-Methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Methylthiazole-5-carboxaldehyde | HCID 581339 | — |
| Reactant | Arsonium, (3-methyl-2-oxobutyl)triphenyl-, bromide | HCID 11465575 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one | HCID 53814806 | — |
Reaction Steps
The title compound was prepared as described in General Method 1 using 1.4 g (11.0 mmol) of 4-methyl-5-thiazolecarbaldehyde (Example A-12), 6.2 g (13.1 mmol) of (3-methyl-2-oxobutyl)triphenylarsonium bromide, 1.8 g (13.1 mmol) of potassium carbonate, 75 mL of acetonitrile, and 0.75 mL of H2O. Chromatography of the residue, eluting with 3:1 hexane:EtOAc gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528510B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-e02cb5f6e03442108d2839b4565fe7a4 |
| Source note | uspto-grants-2003_03 |