HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-Methyl-1-(4-methyl-thiazol-5-yl)-pentan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one | HCID 53814806 | — |
| Catalyst | Pd barium sulfate | HCID 16218511 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Methyl-1-(4-methyl-thiazol-5-yl)-pentan-3-one | HCID 22572781 | — |
Reaction Steps
The title compound was prepared as described in General Method 3 using 1.73 g (8.86 mmol) of 4-methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one (prepared in Example B-1) and 0.4 g of 5% Pd/BaSO4 in THF:MeOH (25 mL:25 mL). The crude product was chromatographed on silica gel, eluting with 2:1 hexane:EtOAc, to give the title compound. 1H NMR (CDCl3): δ1.03 (d, 6 H), 2.35 (s, 3 H), 2.49-2.56 (m, 1 H), 2.72 (t, 2 H), 2.98 (t, 2 H), 8.49 (s, 1 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528510B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-a9d8c5ab1837485797585a367ad4c303 |
| Source note | uspto-grants-2003_03 |