HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trityl chloride → 4-Iodo-1-(triphenylmethyl)-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trityl chloride | HCID 6456 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Iodopyrazole | HCID 77022 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Iodo-1-(triphenylmethyl)-1H-pyrazole | HCID 15324479 | — |
Reaction Steps
The title compound was prepared by combining 4-iodopyrazole (10 g, 52 mmol), triphenylmethyl chloride (14.4 g, 51.6 mmol), triethylamine (NEt3) (7.2 mL, 52 mmol), and DMF (80 mL). After stirring overnight, the mixture was poured onto ice water. The precipitated solid was collected and recrystallized to give the title compound as a solid, mp 193-194° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528510B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-741dea39f16140c18763e6370f730982 |
| Source note | uspto-grants-2003_03 |