Calcium Carbonate → 2-Bromo-5-fluorobenzyl alcohol

Participants

Reaction Steps

2-Bromo-5-fluorobenzylbromide (2.0 g, 7.46 mmol) was dissolved in dioxane (25 mL) and H2O (25 mL), and CaCO3 (3.84 g, 38.39 mmol) was added. The mixture was heated to reflux overnight. The solution was concentrated, and the residue was partitioned between H2O and CH2Cl2. The organic phase was washed with 1N HCl and brine, dried (MgSO4), filtered, and concentrated to afford the title compound. 1H NMR (CDCl3): δ2.00 (t, 1 H), 4.72 (d, 2 H), 6.85-6.92 (m, 1 H), 7.26 (dd, 1 H), 7.48 (dd, 1 H).

Provenance & Evidence