HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 4-Methyl-1-thiophen-3-yl-pentan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-Bromothiophene | HCID 13383 | — |
| Reactant | 4-Methyl-1-penten-3-ol | HCID 20929 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Methyl-1-thiophen-3-yl-pentan-3-one | HCID 12477279 | — |
Reaction Steps
The title compound was prepared according to General Method 4b using 3-bromothiophene (20 mmol), 4-methyl-1-penten-3-ol (30 mmol), sodium iodide (0.7 mmol), sodium bicarbonate (24 mmol), triphenylphosphine (0.6 mmol), DMF (15 mL), and palladium acetate (0.2 mmol). The title compound was flash chromatographed using EtOAc:hexane (5:95 to 10:90).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528510B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-344f539b93384784a326a21ef037d6ff |
| Source note | uspto-grants-2003_03 |