HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (S)-4-Hydroxy-6-isopropyl-6-(2-thiophen-3-yl-ethyl)-5,6-dihydro-pyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (S)-hydroxy-6-methyl-3-oxo-5-(2-thiophen-3-yl-ethyl)-heptanoic acid ethyl ester | HCID 54217641 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (S)-4-Hydroxy-6-isopropyl-6-(2-thiophen-3-yl-ethyl)-5,6-dihydro-pyran-2-one | HCID 54714018 | — |
Reaction Steps
The title compound was prepared as described in General Method 8 using (S)-hydroxy-6-methyl-3-oxo-5-(2-thiophen-3-yl-ethyl)-heptanoic acid ethyl ester (6.4 mmol), 0.1N NaOH (400 mL), and THF (40 mL). The product was triturated from Et2O, mp 117-123° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528510B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-1bb6ce77f40f4fb8a51493fcc78c9726 |
| Source note | uspto-grants-2003_03 |