HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphate → 6-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphate | HCID 1061 | — |
| Reactant | D-1,4-Dithiothreitol | HCID 446094 | — |
| Reactant | 6-tert-Butyl-5-thiocyanato-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester | HCID 54343849 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester | HCID 54077923 | — |
Reaction Steps
The title compound was prepared according to General Method 14 using 6-tert-butyl-5-thiocyanato-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (prepared in Example KK; 2.0 g, 6.6 mmol), dithiothreitol (1.21 g, 7.9 mmol), EtOH (100 mL), and phosphate buffer (pH: 7.5. 10 mL). The crude product was used without any purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528510B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-12e5dedeed054aff8668116be47d6a70 |
| Source note | uspto-grants-2003_03 |