HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 6-tert-Butyl-5-mercapto-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 6-tert-butyl-5-thiocyanato-1H-indole-2-carboxylic acid ethyl ester | HCID 22572772 | — |
| Reactant | Sodium hydrogen sulphide | HCID 86586439 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-tert-Butyl-5-mercapto-1H-indole-2-carboxylic acid ethyl ester | HCID 69736019 | — |
Reaction Steps
The title compound was prepared according to the general Method 14b using (6-tert-butyl-5-thiocyanato-1H-indole-2-carboxylic acid ethyl ester (prepared in Example ZZ; 0.25 g, 0.83 mmol), sodium hydrogen sulfide (0.13 g, 2.48 mmol), sodium borohydride (0.188 g, 4.98 mmol), MeOH (5 mL), and AcOH (1 mL). MS(APCI): 278 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528510B1 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-f1b78852efc14cfdbdaa77f534f3e209 |
| Source note | uspto-grants-2003_03 |