Potassium Carbonate → HCID 9899559, compound

Participants

Reaction Steps

To a 25 mL reaction flask was added 4-bromo-butyric acid methyl ester (2.04 g, 11.2 mmol), compound 3 (1.51 g, 10.8 mmol) and potassium carbonate (1.63 g, 11.8 mmol) suspended in CH3CN (10 mL). The reaction mixture was stirred over-night at rt followed by filtration and evaporation to dryness. Addition of H2O (50 mL) was followed by extraction with ethyl acetate (3×100 mL). The combined organic phases were dried (MgSO4) and evaporated to dryness, to produce 2.84 g of crude 23. The crude product was subjected to CC [eluent:CH2Cl2:MeOH (99:1)] to give pure 23 (1.93 g, 75%). LC-MS [M+H]+ 241 (cald. 241.2).

Provenance & Evidence