HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 3-Amino-4-chloro-N-phenylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-Chloro-3-nitrobenzoic acid | HCID 7320 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 3-Amino-4-chloro-N-phenylbenzamide | HCID 16778069 | 68.9% |
Reaction Steps
Prepared according to the procedure described for Example 1 using oxalyl chloride (2.5 mL, 28.66 mmol), 4-chloro-3-nitrobenzoic acid (4.02 g, 19.94 mmol), DMF (1.0 mL, 12.92 mmol), and aniline (3.6 mL, 39.51 mmol) to afford the product (3.39 g) after trituration in hexane; m.p. 194-197° C. after recrystallization from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528528B2 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-df62c0bcfd924ac7b7866454c620e228 |
| Source note | uspto-grants-2003_03 |