HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 18626234, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3,4-Difluoroaniline | HCID 77469 | — |
| Reactant | 4-Ethyl-3-nitrobenzoic acid | HCID 8167086 | — |
| Product | HCID 18626234 | HCID 18626234 | 89.8% |
Reaction Steps
Prepared according to the procedure described for Example 1 using oxalyl chloride (2.0 mL, 22.93 mmol), 3-nitro-4-ethylbenzoic acid from Example 17, Step A (3.85 g, 19.74 mmol), DMF (1.0 mL, 12.92 mmol), and 3,4-difluoroaniline (4.0 mL, 40.34 mmol) to afford the product (4.9 g); m.p. 108-110° C. after trituration in hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528528B2 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-f82cd3ab788742ecb87524026e445473 |
| Source note | uspto-grants-2003_03 |