3,5-Dichlorophenyl isothiocyanate → HCID 53728276, compound

HRID 1859699Notes

Reaction equation

HRID 1859699 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[O:17][CH2:18][CH3:19])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6].[Cl:20][C:21]1[CH:22]=[C:23]([N:28]=[C:29]=[S:30])[CH:24]=[C:25]([Cl:27])[CH:26]=1>>[Cl:20][C:21]1[CH:22]=[C:23]([NH:28][C:29](=[S:30])[NH:1][C:2]2[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=2[O:17][CH2:18][CH3:19])[C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])[CH:24]=[C:25]([Cl:27])[CH:26]=1

Participants

3

Reactant 2

HCID 1387763,5-Dichlorophenyl isothiocyanateHCID 18626166HCID 18626166, compound

Product 1

HCID 53728276HCID 53728276, compoundYield 77%

Procedure

Prepared according to the procedure described for Example 60 using 3-amino-4-ethoxy-N-phenyl-benzamide from Example 10 (0.335 g, 1.30 mmol) and 3,5-dichlorophenyl isothiocyanate (0.266 g, 1.30 mmol) to give the product (0.4609 g); m.p. 201-202° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0b6cf480f1bf49ca882221a22667a349
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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