3-Amino-4-methoxybenzanilide → HCID 54236288, compound

HRID 1859702Notes

Reaction equation

HRID 1859702 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6].[Cl:19][C:20]1[CH:21]=[C:22]([N:27]=[C:28]=[S:29])[CH:23]=[CH:24][C:25]=1[Cl:26]>>[Cl:19][C:20]1[CH:21]=[C:22]([NH:27][C:28](=[S:29])[NH:1][C:2]2[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=2[O:17][CH3:18])[C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])[CH:23]=[CH:24][C:25]=1[Cl:26]

Participants

3

Reactant 2

HCID 84263-Amino-4-methoxybenzanilideHCID 230651,2-Dichloro-4-isothiocyanatobenzene

Product 1

HCID 54236288HCID 54236288, compoundYield 78.4%

Procedure

Prepared according to the procedure described for Example 60 using 3-amino-4-methoxy-N-phenyl-benzamide (0.972 g, 4.00 mmol) and 3,4-dichlorophenyl isothiocyanate (0.82 g, 4.02 mmol) to afford the product (1.40 g) in two crops; m.p. 174-175° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-cf5ced8e74b4491cbd305239909ecc10
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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