3,5-Dichlorophenyl isothiocyanate → HCID 54090344, compound

HRID 1859703Notes

Reaction equation

HRID 1859703 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Cl:20][C:21]1[CH:22]=[C:23]([N:28]=[C:29]=[S:30])[CH:24]=[C:25]([Cl:27])[CH:26]=1>>[Cl:20][C:21]1[CH:22]=[C:23]([NH:28][C:29](=[S:30])[NH:1][C:2]2[CH:3]=[C:4]([NH:10][C:11]([NH:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[CH:5]=[CH:6][C:7]=2[O:8][CH3:9])[CH:24]=[C:25]([Cl:27])[CH:26]=1

Participants

3

Reactant 2

HCID 1387763,5-Dichlorophenyl isothiocyanateHCID 18626050HCID 18626050, compound

Product 1

HCID 54090344HCID 54090344, compoundYield 74%

Procedure

Prepared according to the procedure described for Example 78 using 1-(4-methoxy-3-aminophenyl)-3-phenyl-urea from Example 24, Step C (0.390 g, 1.52 mmol) and 3,5-dichlorophenyl isothiocyanate (0.311 g, 1.52 mmol). Filtration without trituration afforded the product (0.5187 g); m.p. 218-219° C.

Workup

  1. customPrepared
  2. filtrationFiltration without trituration

Sources & evidence

ORD record
ord-4e079c473dd84edc94e3b6f9fb7c6806
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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