3,5-Dichlorophenyl isothiocyanate → HCID 21715912, compound

HRID 1859708Notes

Reaction equation

HRID 1859708 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[O:18][CH3:19])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)=[O:6].[Cl:20][C:21]1[CH:22]=[C:23]([N:28]=[C:29]=[S:30])[CH:24]=[C:25]([Cl:27])[CH:26]=1>>[Cl:20][C:21]1[CH:22]=[C:23]([NH:28][C:29](=[S:30])[NH:1][C:2]2[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=2[O:18][CH3:19])[C:5]([NH:7][C:8]2[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=2)=[O:6])[CH:24]=[C:25]([Cl:27])[CH:26]=1

Participants

3

Reactant 2

HCID 1387763,5-Dichlorophenyl isothiocyanateHCID 16781168HCID 16781168, compound

Product 1

HCID 21715912HCID 21715912, compoundYield 76.5%

Procedure

Prepared according to the procedure described for Example 60 using 3-amino-N-(4-fluorophenyl)-4-methoxy-benzamide from Example 8 (0.520 g, 2.00 mmol) and 3,5-dichlorophenyl isothiocyanate (0.409 g, 2.00 mmol). Filtration afforded the product (0.71 g) in two crops; m.p. 175-178° C.

Workup

  1. customPrepared
  2. filtrationFiltration

Sources & evidence

ORD record
ord-96209e67256e4e499595fa6a4a03f669
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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