3,5-Dichlorophenyl isothiocyanate → HCID 54157895, compound

HRID 1859716Notes

Reaction equation

HRID 1859716 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:17])=[C:6]([CH:16]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:8].[Cl:18][C:19]1[CH:20]=[C:21]([N:26]=[C:27]=[S:28])[CH:22]=[C:23]([Cl:25])[CH:24]=1>>[Cl:18][C:19]1[CH:20]=[C:21]([NH:26][C:27](=[S:28])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([F:17])=[C:6]([CH:16]=2)[C:7]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:8])[CH:22]=[C:23]([Cl:25])[CH:24]=1

Participants

3

Reactant 2

HCID 1387763,5-Dichlorophenyl isothiocyanateHCID 18626059HCID 18626059, compound

Product 1

HCID 54157895HCID 54157895, compoundYield 87.5%

Procedure

Prepared according to the procedure described for Example 60 using 5-amino-2-fluoro-N-phenyl-benzamide (0.920 g, 4.00 mmol) and 3,5-dichlorophenyl isothiocyanate (0.817 g, 4.00 mmol) to afford the product (1.52 g); m.p. 195-196° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5c0a1b55ef404607abea8919373883b1
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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