Benzenesulfonyl chloride, 3,4-dichloro- → 3-(3,4-Dichloro-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamide

HRID 1859740Notes

Reaction equation

HRID 1859740 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9](Cl)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:13][C:14]1[CH:15]=[C:16]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:18]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:13][C:14]2[CH:15]=[C:16]([CH:26]=[CH:27][C:28]=2[O:29][CH3:30])[C:17]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:18])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 7383Benzenesulfonyl chloride, 3,4-dichloro-HCID 84263-Amino-4-methoxybenzanilide

Product 1

HCID 186262403-(3,4-Dichloro-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamideYield 92.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared according to the procedure described for Example 121 using 3,4-dichlorobenzenesulfonyl chloride (2.45 g, 10 mmol), 3-amino-4-methoxy-N-phenyl-benzamide (2.43 g, 10 mmol) and pyridine (25 mL) to afford the product (4.183 g); m.p. 191-193° C. after trituration in hexanes/ethyl acetate (1:1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dffcd0728a6145f2bb187d18131fc7df
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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