Water → HCID 18626573, compound

Participants

Reaction Steps

2.8 g of ethyl 2-(4-chlorophenyl)-5,5-bis(4-fluorophenyl)-[1,3]dioxane-2-carboxylate are refluxed for 7 hours in 60 ml of methanol and 15 ml of water containing 0.7 g of NaOH. After concentrating, the residue is diluted with water and stirred until a solution is obtained. This solution is washed with ether and the aqueous phase is acidified with HCl. The solid formed is filtered off and washed with water and pentane. The product is recrystallized from 100 ml of toluene. (m.p.=228-30° C.; weight obtained 1.9 g).

Provenance & Evidence