2-Thiophenecarboxaldehyde → HCID 53956948, compound

Participants

Reaction Steps

According to the method of Example 8, 6-(2-imidazole-1-yl-ethoxy)-3,4-dihydro-2H-naphthalen-1-one (0.400 g, 1.56 mmol) was reacted with 2-thiophene carboxaldehyde (0.264 g, 2.35 mmol) in 5.0 mL of 4% KOH in EtOH for 4.5 hours at room temperature to afford 0.369 g (67%) of the title compound as dark yellow crystals, mp 137-138° C.: CI-MS m/e 350 (M+), 351 M++1);

Provenance & Evidence