Methanol → Methyl 3-hydroxy-2-methylbenzoate

Participants

Reaction Steps

A solution of 17.98 g (0.118 mol) of 3-hydroxy-2-methylbenzoic acid in 200 L of MeOH was treated with 2.0 mL of conc. H2SO4 and heated at reflux overnight. The solution was concentrated under reduced pressure and diluted with H2O. The product was collected and recrystallized from MeOH/H2O to give 12.85 g (65.6% yield) of a tan solid, mp 74-75° C. The structure was confirmed by NMR and mass spectroscopy. MS m/z 167 (M+H+).

Provenance & Evidence