Sodium Hydroxide → HCID 10255705, compound

HRID 1859853Notes

Reaction equation

HRID 1859853 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH:10]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][NH:26][C:27](=[O:40])[C:28]3[CH:33]=[CH:32][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:30][CH:29]=3)=[CH:19][CH:18]=2)[C:11]([O:13]CC)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([CH2:7][CH2:8][CH2:9][CH:10]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][NH:26][C:27](=[O:40])[C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:32][CH:33]=3)=[CH:19][CH:18]=2)[C:11]([OH:13])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625880HCID 18625880, compound

Product 1

HCID 10255705HCID 10255705, compoundYield 49.7%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(3-phenylpropyl)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (767 mg), which is the product of Example 3, was reacted with an aqueous sodium hydroxide solution (1N, 2.86 ml) and the reaction mixture was treated. The residue was crystallized from a mixture of diisopropyl ether and ethyl acetate to give the title compound (361 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated
  2. customThe residue was crystallized from a mixture of diisopropyl ether and ethyl acetate

Sources & evidence

ORD record
ord-3347712f580f43cbad2796d3539d9011
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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