Sodium Hydroxide → HCID 10436847, compound

HRID 1859855Notes

Reaction equation

[CH:1]([C:4]1[CH:41]=[CH:40][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26](=[O:39])[C:27]3[CH:32]=[CH:31][C:30]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=4)=[CH:29][CH:28]=3)=[CH:18][CH:17]=2)[C:10]([O:12]CC)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26](=[O:39])[C:27]3[CH:28]=[CH:29][C:30]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=4)=[CH:31][CH:32]=3)=[CH:18][CH:17]=2)[C:10]([OH:12])=[O:11])=[CH:40][CH:41]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625824HCID 18625824, compound

Product 1

HCID 10436847HCID 10436847, compoundYield 99.9%

Procedure

In a similar manner to that described in Example 2, ethyl 2-(4-isopropylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (8.38 g), which is the product of Example 9, was reacted with aqueous sodium hydroxide solution (1N, 30.32 ml) and the reaction mixture was treated to give the title compound (7.95 g) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-197c5f6eacb441f09f1c004e147c71aa
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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