Sodium Hydroxide → HCID 10026588, compound

HRID 1859856Notes

Reaction equation

HRID 1859856 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22](=[O:35])[C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=3)=[CH:25][CH:24]=2)=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22](=[O:35])[C:23]2[CH:24]=[CH:25][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=3)=[CH:27][CH:28]=2)=[CH:14][CH:13]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625807HCID 18625807, compound

Product 1

HCID 10026588HCID 10026588, compoundYield 122.5%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (0.92 g), which is the product of Example 11, was reacted with aqueous sodium hydroxide solution (1N, 3.80 ml) and the reaction mixture was treated to give the title compound (1.06 g) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-4f457dbc7a23497da28e940cd9be8fc7
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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