Sodium Hydroxide → HCID 9983291, compound

HRID 1859857Notes

Reaction equation

HRID 1859857 reaction equation
[CH3:1][C:2]([O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][NH:18][C:19](=[O:32])[C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)=[CH:22][CH:21]=2)=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+]>>[CH3:1][C:2]([O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH2:16][CH2:17][NH:18][C:19](=[O:32])[C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)=[CH:22][CH:21]=2)=[CH:13][CH:14]=1)[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625847HCID 18625847, compound

Product 1

HCID 9983291HCID 9983291, compoundYield 61.9%

Procedure

In a similar manner to that described in Example 2, ethyl 2-methyl-2-phenoxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (930 mg), which is the product of Example 15, was reacted with aqueous sodium hydroxide solution (1N, 3.60 ml) at 70° C. and the reaction mixture was treated to give the title compound (545 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-9bf629a970aa4860b295aecee3423993
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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