Potassium Hydroxide → HCID 10030159, compound

HRID 1859858Notes

Reaction equation

HRID 1859858 reaction equation
[CH:1]([C:4]1[CH:42]=[CH:41][C:7]([O:8][C:9]([CH3:40])([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26](=[O:39])[C:27]3[CH:32]=[CH:31][C:30]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=4)=[CH:29][CH:28]=3)=[CH:18][CH:17]=2)[C:10]([O:12]CC)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[K+]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]([CH3:40])([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][NH:25][C:26](=[O:39])[C:27]3[CH:28]=[CH:29][C:30]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=4)=[CH:31][CH:32]=3)=[CH:18][CH:17]=2)[C:10]([OH:12])=[O:11])=[CH:41][CH:42]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 18625733HCID 18625733, compound

Product 1

HCID 10030159HCID 10030159, compoundYield 72.5%

Procedure

In a similar manner to that described in Example 6, ethyl 2-(4-isopropylphenoxy)-2-methyl-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (486 mg), which is the product of Example 17, was reacted with aqueous potassium hydroxide solution (85%, 0.17 g) and the reaction mixture was treated. The residue was washed with diisopropyl ether to give the title compound (335 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated
  2. washThe residue was washed with diisopropyl ether

Sources & evidence

ORD record
ord-38172bfa3f784138bc3e7d88730e0746
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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