Potassium Hydroxide → HCID 17795647, compound

HRID 1859859Notes

Reaction equation

HRID 1859859 reaction equation
[CH2:1]([C:5]([CH3:36])([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22](=[O:35])[C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=3)=[CH:25][CH:24]=2)=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+].[OH-].[K+]>ClCCl.CO>[CH2:1]([C:5]([CH3:36])([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22](=[O:35])[C:23]2[CH:24]=[CH:25][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=3)=[CH:27][CH:28]=2)=[CH:14][CH:13]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 18625953HCID 18625953, compound

Product 1

HCID 17795647HCID 17795647, compoundYield 40.3%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

In a similar manner to that described in Example 6, ethyl 2-butyl-2-methyl-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (350 mg), which is the product of Example 19, was reacted with aqueous sodium hydroxide solution (1N, 2.00 ml) and aqueous potassium hydroxide solution (85%, 0.1g) and the reaction mixture was treated. The residue was subjected to chromatography on a silica gel column using dichlorometane/methanol=19/1 as the eluant to afford a solid which was washed with a mixture of diisopropyl ether and hexane to give the title compound (133 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated
  2. customto afford a solid which
  3. washwas washed with a mixture of diisopropyl ether and hexane

Sources & evidence

ORD record
ord-710a1da5ad234ceeb2d236e634697110
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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