Sodium Hydroxide → 3-[4-[2-(Biphenyl-4-carbonylamino)ethoxy]phenyl]-2-butylpropionic acid

HRID 1859860Notes

Reaction equation

HRID 1859860 reaction equation
[C:1]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:6]=[CH:5][C:4]([C:7]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([CH2:26][CH2:27][CH2:28][CH3:29])[C:21]([O:23]CC)=[O:22])=[CH:15][CH:14]=2)=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:6]=[CH:5][C:4]([C:7]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([CH2:26][CH2:27][CH2:28][CH3:29])[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=2)=[O:8])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18625927Ethyl 3-[4-[2-(biphenyl-4-carbonylamino)ethoxy]phenyl]-2-butylpropionate

Product 1

HCID 103888283-[4-[2-(Biphenyl-4-carbonylamino)ethoxy]phenyl]-2-butylpropionic acidYield 91.7%

Procedure

In a similar manner to that described in Example 2, ethyl 3-[4-[2-(biphenyl-4-carbonylamino)ethoxy]phenyl]-2-butylpropionate (450 mg), which is the product of Example 21, was reacted with aqueous sodium hydroxide solution (1N, 3.00 ml) and the reaction mixture was treated to give the title compound (388 mg) as a white powder.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-12e83f69da3d4a1fbcaa1d2e396c7aa0
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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