Sodium Hydroxide → HCID 17795620, compound

HRID 1859861Notes

Reaction equation

[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:31]=[CH:32][C:33]([O:36][CH3:37])=[CH:34][CH:35]=3)=[CH:28][CH:29]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625925HCID 18625925, compound

Product 1

HCID 17795620HCID 17795620, compoundYield 92.7%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(4′-methoxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (400 mg), which is the product of Example 23, was reacted with aqueous sodium hydroxide solution (1N, 4.00 ml) and the reaction mixture was treated to give the title compound (350 mg) as a pale orange powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-36c7ce8e56b34b88a804907aa4c1527e
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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