Sodium Hydroxide → 2-Butyl-3-[4-[2-(3'-dimethoxymethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionic acid

Participants

Reaction Steps

In a similar manner to that described in Example 27, ethyl 2-butyl-3-[4-[2-(3′-dimethoxymethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (1.46 g), which is the product of Reference example 14, was reacted with aqueous sodium hydroxide solution (1N, 5.40 ml) and the reaction mixture was treated to give 2-butyl-3-[4-[2-(3′-dimethoxymethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionic acid (1.39 g) as a syrup. This compound (365 mg) was reacted and the reaction mixture was treated in a similar manner to that described in Example 27 to give the title compound (335 mg) as a yellowish brown solid.

Provenance & Evidence