Sodium Hydroxide → HCID 17795703, compound

HRID 1859870Notes

Reaction equation

[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([CH2:36][N:37]([CH3:39])[CH3:38])[CH:31]=3)=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([CH2:36][N:37]([CH3:38])[CH3:39])[CH:31]=3)=[CH:28][CH:29]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625810HCID 18625810, compound

Product 1

HCID 17795703HCID 17795703, compoundYield 48.6%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(3′-dimethylaminomethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (263 mg), which is the product of Example 38, was reacted with aqueous sodium hydroxide solution (1N, 1.00 ml) and the reaction mixture was treated to give the title compound (121 mg) as a white powder.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-f3375914b2af4b6188c23e2289d80627
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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