Sodium Hydroxide → HCID 17795763, compound

HRID 1859874Notes

Reaction equation

HRID 1859874 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[CH:36]=[O:37])=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>ClCCl.CO>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[CH:36]=[O:37])=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18625973HCID 18625973, compound

Product 1

HCID 17795763HCID 17795763, compoundYield 51.3%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(2′-formylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (314 mg), which is the product of Example 46, was reacted with aqueous sodium hydroxide solution (1N, 2.50 ml) and the reaction mixture was treated to afford the crude free acid which was subjected to chromatography on a silica gel thin layer plate using dichloromethane/methanol=10/1 as the eluant to give the title compound (152 mg) as a mass of foam.

Workup

  1. additionthe reaction mixture was treated
  2. customto afford the crude free acid which

Sources & evidence

ORD record
ord-7c5fae915e8543fa84c353b05f37e0d1
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

Loading…